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Clinical Studies

Eurycoma longifolia jack (Tongkat Ali) induces penile erection and delays ejaculation


9-hydroxycanthin-6-one, an active compound found in Eurycoma longifolia jack, contributed to the aphrodisiac effect by antagonizing the smooth muscle tone of corpus cavernosum as well as the seminal vesicle through interfering with Ca2+ mobilization.

 Click here for Detailed Study:- https://www.ncbi.nlm.nih.gov/pubmed/21569213

Effect of Lepidium meyenii (MACA) on sexual desire and its absent relationship with serum testosterone levels in adult healthy men.


Logistic regression analysis showed that Maca has an independent effect on sexual desire at 8 and 12 weeks of treatment, and this effect is not because of changes in either Hamilton scores for depression or anxiety or serum testosterone and oestradiol levels. In conclusion, treatment with Maca improved sexual desire.

 Click here for Detailed Study:- https://www.ncbi.nlm.nih.gov/pubmed/12472620

The hormonal effects of Tribulus terrestris and its role in the management of male erectile dysfunction–an evaluation using primates, rabbit and rat.


In castrated rats, increases in T levels by 51% and 25% were observed with T and TT extract respectively that were statistically significant. TT increases some of the sex hormones, possibly due to the presence of protodioscin in the extract. TT may be useful in mild to moderate cases of ED.

 Click here for Detailed Study:- https://www.ncbi.nlm.nih.gov/pubmed/18068966

Effect of Tongkat Ali on stress hormones and psychological mood state in moderately stressed subjects


Stress hormone profile (salivary cortisol and testosterone) was significantly improved by TA supplementation, with reduced cortisol exposure (−16%) and increased testosterone status (+37%). These results indicate that daily supplementation with tongkat ali root extract improves stress hormone profile and certain mood state parameters, suggesting that this “ancient” remedy may be an effective approach to shielding the body from the detrimental effects of “modern” chronic stress, which may include general day-to-day stress, as well as the stress of dieting, sleep deprivation, and exercise training.

 Click here for Detailed Study:- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669033

Randomized Clinical Trial on the Use of PHYSTA Freeze-Dried Water Extract of Eurycoma longifolia for the Improvement of Quality of Life and Sexual Well-Being in Men.


Eurycoma longifolia is reputed as an aphrodisiac and remedy for decreased male libido.

The EL group showed higher scores in the overall Erectile Function domain in IIEF (P < 0.001), sexual libido (14% by week 12), SFA- with sperm motility at 44.4%, and semen volume at 18.2% at the end of treatment. Subjects with BMI ≥ 25 kg/m(2) significantly improved in fat mass lost (P = 0.008). All safety parameters were comparable to placebo.

 Click here for Detailed Study:- https://www.ncbi.nlm.nih.gov/pubmed/23243445

Study of the efficacy of Korean Red Ginseng in the treatment of erectile dysfunction.


In the KRG group, 20 patients (66.6%), reported improved erection, significant in the global efficacy question (P < 0.01); in the placebo group there was no significance.


Our data show that KRG can be an effective alternative to the invasive approaches for treating male ED.

 Click here for Detailed Study:- https://www.ncbi.nlm.nih.gov/pubmed/16855773

Induction of nitric oxide synthase expression by Withania somnifera in macrophages.


we investigated the effect of a methanolic extract from the root of Withania somnifera (WS) on nitric oxide (NO) production in J774 macrophages. The increased NO production by macrophages could account, at least in part, for the immunostimulant properties of Withania somnifera.

 Click here for Detailed Study:- https://www.ncbi.nlm.nih.gov/pubmed/12551750

A double-blind, randomized, pilot dose-finding study of maca root (L. meyenii) for the management of SSRI-induced sexual dysfunction.


Libido improved significantly (P<0.05) for the ITT and completer groups based on ASEX item #1, but not by dosing groups. Maca was well tolerated. Maca root may alleviate SSRI-induced sexual dysfunction, and there may be a dose-related effect. Maca may also have a beneficial effect on libido.

 Click here for Detailed Study:- https://www.ncbi.nlm.nih.gov/pubmed/18801111

Clinical study of Tribulus terrestris Linn. in Oligozoospermia: A double blind study.


Infertility is a problem of global proportions, affecting on an average 8-12% of couples worldwide. he Gokshura granules have shown superior results in the management of Kshina Shukra, as compared to the placebo granules.

 Click here for Detailed Study:- https://www.ncbi.nlm.nih.gov/pubmed/23723641

A pilot investigation into the effect of maca supplementation on physical activity and sexual desire in sportsmen.


14 days ME supplementation improved 40 km cycling time trial performance and sexual desire in trained male cyclists. These promising results encourage long-term clinical studies involving more volunteers, to further evaluate the efficacy of ME in athletes and normal individuals and also to explore its possible mechanisms of action.

 Click here for Detailed Study:- https://www.ncbi.nlm.nih.gov/pubmed/19781622


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